Submit Manuscript  

Article Details


Would Polymorphic Variants of Dopamine-2 Receptor Gene (DRD2) and Serotonin Transporter Gene (SERT) be a Common Genetic Risk Factor for Comorbid Drug Abuse and Myocardial Ischemia? A Hypothesis- generating Study

[ Vol. 15 , Issue. 2 ]

Author(s):

Yasmeen M. Taalab*, Doaa A. Elmorsi, Imke Puls, Andreas Heinz, Abdel-Aziz Ghanem, Seham Gad-ElHak and Mohammad Al-Haggar   Pages 129 - 143 ( 15 )

Abstract:


Background: A variety of genetic pathways have been described as being essential in drug abuse and myocardial ischemia (MI), including dopamine-2 receptor gene (DRD2) and serotonin transporter gene (SERT). However, there is insufficient information on how those genetic pathways could contribute to their comorbidity.

Objectives: The study aimed to examine the potential association between drug abuse/myocardial ischemia comorbidity and five single nucleotide polymorphisms (SNPs) of DRD2 gene; Taq IA, Taq IB, Taq ID, -241A>G, and -141C del/ins, and two SNPs of SERT gene; 5-HTTLPR (rs25531) and an intronic variant (Stin2).

Method: Fifteen Egyptian families including 211 individuals and 75 control subjects were genotyped using PCR-RFLP assay method. All individuals were assessed using drug use survey and complete cardiovascular profile.

Results: The odds ratio (OR) for comorbidity with early onset MI associated with the A1A1 genotype of TaqIA was 3.9 (95% CI=1.8-8.5). However, B1B1 and B1B2 genotypes of TaqIB were significant in comorbidity of early onset drug abuse phenotype (OR =2.6, 95% CI=1.4-5.2 and OR=1.7 and 95% CI=1.2-2.5 respectively). Genotype AG of - 241A˃G showed higher risk among comorbid subjects of early onset drug abuse (OR=1.9, 95% CI=1.4-2.7) and ins-containing genotypes of -141C del/ins were significant in comorbidity. Regarding SERT gene, SLA genotype of 5-HTTLPR and 10/10 of STin2 were significantly associated with comorbidity of early onset MI with OR=1.5, 95% CI=1.1-2.2 and OR=3.3, 95% CI=1.5-6.9.

Conclusion: SNPs of the studied genes have made a significant contribution to comorbidity however, further studies are needed to validate the results in a wider population.

Keywords:

Comorbidity, gene polymorphism, drug abuse, myocardial ischemia, DRD2, SERT, SNPs.

Affiliation:

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Department of Psychiatry and Psychotherapy, Charite Universitatmedizin, Berlin, Department of Psychiatry and Psychotherapy, Charite Universitatmedizin, Berlin, Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Pediatrics and Genetics, Mansoura University Children's Hospital (MUCH), Mansoura

Graphical Abstract:



Read Full-Text article