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Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations

[ Vol. 16 , Issue. 3 ]

Author(s):

Dmitry L. Maslov*, Elena E. Balashova, Oxana P. Trifonova and Petr G. Lokhov   Pages 192 - 198 ( 7 )

Abstract:


Background: A patient-focused approach to treatment, where individual characteristics provide the selection of optimal medication strategy for a particular patient, is the trend of current clinical therapy. An application of advanced “omics” technologies, which enable to detect the inter-individual variability in genomic, transcriptomic, proteomic, and metabolomic levels is a perspective way to achieve such personalization.

Objective: In this review, the advantages of metabolomics-based approach as one of the most promising and perspective for individualization of pharmacotherapy are demonstrated. This approach provides a prediction of the inter-individual variability in drug response and allows monitoring effectiveness of drug treatment, correcting it in account of individual parameters of patients.

Method: Comparative analysis of metabolomics-based approach and the current methods of drug treatment personalization are carried out.

Results: Advantages and limitations of the metabolomics-based approach were identified and discussed.

Conclusion: The perspective ways for solution of limitations of the metabolomics-based approach are considered.

Keywords:

Metabolomics, pharmacometabolomics, pharmacogenomics, personalized medicine, mass spectrometry, metabolomics-based approach.

Affiliation:

Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow

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