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HLA-B27 is a Risk Factor for Rheumatoid Arthritis: Suggestion for an Evidence-based Update

[ Vol. 17 , Issue. 1 ]


Seyyed Amir Yasin Ahmadi, Reza Mohammadrezaei-Khorramabadi, Saber Abbaszadeh, Jafar Rezaian and Farhad Shahsavar*   Pages 7 - 10 ( 4 )


Previously, the association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis has been investigated as original and meta-analysis studies. However, the association of HLA-B27 with rheumatoid arthritis is not currently investigated as a meta-analysis. Hence, in this letter, a brief meta-analysis on this association will be performed. Although there were some studies on the association of RA and HLA-B27, however, there was not a pooled odds ratio reported in textbooks. Based on this brief metaanalysis, number 2.687 can be reported as the odds ratio of this association. It shows that this association is neither sensitive nor specific, but can be an idea for pharmacogenomics and personalized medicine as a potential risk factor. Such other associations should be reported numerically and updated in textbooks.


HLA-B27, rheumatoid arthritis, meta-analysis, personalized medicine, human leukocyte antigen, immunogenic peptides.


Student Research Committee, Iran University of Medical Sciences, Tehran, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Department of Biochemistry, Lorestan University of Medical Sciences, Khorramabad, Scientific Society of Evidence-based Knowledge, Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Department of Immunology, Lorestan University of Medical Sciences, Khorramabad

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