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Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications

[ Vol. 18 , Issue. 1 ]

Author(s):

Maja Stoneberg*, Natasha Petry, Carlina Grindeland, Monte Roemmich, Amanda Massmann, Jordan Baye and April Schultz   Pages 51 - 55 ( 5 )

Abstract:


Background: The impact of personalized medicine is potentially enormous, but the genetic results are often difficult to integrate into health settings. A number of research studies are emerging to aid in translating pharmacogenomics into clinical practice.

Objective: We aimed to create a standardized process to guide the implementation of dose adjustment recommendations into the electronic health record (EHR).

Materials and Methods: Monographs were created for selected drug-gene pairs, allowing for a standardized review of available evidence. A scoring template was developed to assess whether the evidence presented in the drug monograph qualified the mentioned drug-gene pair for Clinical Decision Support (CDS) within the EHR.

Results: Of nine medications reviewed, only one drug-gene pair qualified for a CDS proposal to the institution’s governing pharmacogenomics committee.

Conclusion: This project resulted in the development of a standard process for reviewing pharmacogenomics- related literature, allowing for more CDS proposals to be accepted.

Keywords:

Pharmacogenomics, Clinical Decision Support (CDS), primary literature, standardized review, drug-gene monographs, psychotropic.

Affiliation:

Department of Pharmacy, Sanford Health Fargo, Fargo, ND58104, Sanford Health Imagenetics, Sioux Falls, SD57105, Department of Pharmacy, Sanford Health Fargo, Fargo, ND58104, Department of Pharmacy, Sanford Health Fargo, Fargo, ND58104, Sanford Health Imagenetics, Sioux Falls, SD57105, Sanford Health Imagenetics, Sioux Falls, SD57105, Sanford Health Imagenetics, Sioux Falls, SD57105

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