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Genomics and Pharmacogenomics of Age-related Hearing Loss

Author(s):

Joaquin Guerra*, Vinogran Naidoo and Ramon Cacabelos   Pages 1 - 19 ( 19 )

Abstract:


Age-related hearing loss (ARHL) or presbycusis shares common features with conditions related to senescence and neurodegeneration. In this review, we explore the linking of genes involved in such processes with presbycusis, that has been proven to share important relationships with genes involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics (NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative disorders. Moreover, preliminary epigenetics studies have recently identified links in human genes involved in ARHL, which could serve as biomarkers or as therapeutic targets.

Keywords:

presbycusis, genomics, pharmacogenomics, age-related hearing loss, APOE, NAT2, MTHFR

Affiliation:

EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, Bergondo 15165 Corunna, EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, Bergondo 15165 Corunna, EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, Bergondo 15165 Corunna



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